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Quantitative Correlation Between Genetic Variants and Complex Binding Affinity Under Environmental Changes Revealed via Protein Fragment Complementation Assay
Large-scale Elucidation of Protein Interaction Quantitative Trait Loci (piQTLs) Reveals a New Pathway in Which Genetic Variants Cause Disease
Viral DNA Lurking in the Host Genome Induced into Permanent Silence via Epigenetic Target Methylation
Finding Clues for Healing Diabetic Chronic Ulcers by Regulating Macrophage Phenotype Switching
Overcoming Delivery Barriers and High Costs of SMA Therapeutics with Next-Generation Biomaterials
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Quantitative Correlation Between Genetic Variants and Complex Binding Affinity Under Environmental Changes Revealed via Protein Fragment Complementation Assay
Background While advancements in genome sequencing have uncovered numerous genetic variants, determining the actual biochemical changes these variants cause within cells remains a difficult challenge. Previous genomic studies have primarily focused on changes in the expression levels of single proteins or whether protein structure collapses due to amino acid…
Large-scale Elucidation of Protein Interaction Quantitative Trait Loci (piQTLs) Reveals a New Pathway in Which Genetic Variants Cause Disease
Background Genome-wide association studies (GWAS) have revealed links between numerous genetic variants and phenotypes, but most of these variants are located in non-coding regions that do not directly change protein amino acids. The academic community has regarded these variants as expression quantitative trait loci (eQTL) that regulate the messenger RNA (m…
Viral DNA Lurking in the Host Genome Induced into Permanent Silence via Epigenetic Target Methylation
Background Pathogenic viruses such as Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Herpes Simplex Virus penetrate host cells and hide their genetic material by integrating into the host genome or existing as circular episomes. While antiviral drugs can suppress viral replication in the blood, they cannot eliminate the latent reservoirs hi…
Finding Clues for Healing Diabetic Chronic Ulcers by Regulating Macrophage Phenotype Switching
Background One in four diabetic patients experiences chronic wounds, such as diabetic foot ulcers, at least once in their lifetime. Most diabetes-related lower limb amputations stem from the worsening of these chronic ulcers. In a normal wound healing process, macrophages that drive the inflammatory response must timely transition into reparative macrophages…
Overcoming Delivery Barriers and High Costs of SMA Therapeutics with Next-Generation Biomaterials
Background Spinal Muscular Atrophy (SMA) is a rare genetic disorder where muscles gradually atrophy due to the degeneration of spinal anterior horn motor neurons. It is caused by a deficiency in the essential SMN (Survival Motor Neuron) protein due to a loss of the SMN1 gene. While treatments were previously limited to conservative management like respirator…
Vaginal Microbiome Map Created with 65,000 Genomes Reveals Traces of Host Genes and Population of Origin
Background The vaginal microbiome is closely linked to women's reproductive health, including bacterial vaginosis, Human Papillomavirus (HPV) infection, and preterm birth. However, the 16S rRNA analysis commonly used in existing studies struggles to distinguish bacteria at the species/strain level and fails to capture viruses and fungi. Furthermore, sample c…
DepPrior: A Framework for Identifying Lung Adenocarcinoma Targets Integrating CRISPR Gene Dependency and Multi-omics
Background Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and exhibits extreme molecular heterogeneity. While the introduction of Epidermal Growth Factor Receptor (EGFR) or Anaplastic Lymphoma Kinase (ALK) inhibitors has improved treatment outcomes, many patients progress due to a lack of targetable mutations or the acquisit…
Evolution of CRISPR Genome Editing and Next-Generation Delivery Technologies to Overcome Refractoriness in Prostate Cancer Treatment
Background Prostate cancer, a leading cause of cancer-related death in men, is a difficult-to-treat intractable disease due to high molecular heterogeneity within tumor tissues. Current clinical practice primarily relies on Androgen Deprivation Therapy (ADT) and targeted anticancer drugs. While most patients respond to initial treatment, they eventually deve…
Simultaneous Targeting of CD19 and BCMA with CAR-T Cell Therapy Paves the Way for Transplantation in Highly Sensitized ESRD Patients
Background For patients with End-Stage Renal Disease (ESRD) awaiting organ transplantation, the harshest barrier is the antibody defense wall built by the body's immune system. Highly sensitized patients, who have formed anti-Human Leukocyte Antigen (HLA) antibodies due to past pregnancy, blood transfusions, or previous organ transplants, are immediately dis…
Beyond M1/M2 Dichotomy: Macrophage Immunometabolism Identified as Mechanism for Sequential Damage in Heart, Liver, and Kidney Complex Diseases
Background As the prevalence of obesity and type 2 diabetes surges, there is an increasing number of patients with complex metabolic diseases characterized by simultaneous dysfunction of the heart, liver, and kidneys. In clinical practice, cases where Cardiovascular-Kidney-Metabolic (CKM) syndrome or metabolic dysfunction-associated steatohepatitis (MASH) ra…