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SAIGE-QTL Overcomes Limitations in Discovering Single-Cell Transcriptomic Variants Using Poisson Mixed Models
DNA Damage Response Interaction Map and Synthetic Lethality Network Constructed via Cas12a Multiplex Editing Screening
Piezoelectric toothbrush bristles generate power from brushing pressure to remove oral biofilm by inducing reactive oxygen species
dCas9 Epigenome Editing Without Base Sequence Damage: A New Horizon for Breeding Climate-Resilient Crops Against Climate Crisis
Next-Generation mRNA Cervical Cancer Vaccine Inducing Immunity Comparable to Gardasil-9 and the Establishment of Protective Thresholds
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SAIGE-QTL Overcomes Limitations in Discovering Single-Cell Transcriptomic Variants Using Poisson Mixed Models
Background Expression Quantitative Trait Loci (eQTL) analysis, which identifies the impact of genomic variants on gene expression, has become a standard approach for interpreting the functions of disease-associated variants. Recently, advancements in single-cell transcriptome analysis (scRNA-seq) technology have fueled research into cell-type-specific eQTLs…
DNA Damage Response Interaction Map and Synthetic Lethality Network Constructed via Cas12a Multiplex Editing Screening
Background Cells constantly repair genomic damage caused by UV radiation, chemicals, and metabolic byproducts. The complexly intertwined DNA damage response (DDR) signaling network serves as a key defense line for maintaining genomic stability. Defects in this pathway lead to accumulated genomic instability, resulting in cancer. Paradoxically, these DDR defe…
Piezoelectric toothbrush bristles generate power from brushing pressure to remove oral biofilm by inducing reactive oxygen species
Background Daily brushing is a fundamental method for preventing oral diseases. Traditional toothbrushes have relied on the physical friction of nylon micro-bristles and surfactants in toothpaste to scrape plaque from tooth surfaces. The problem is that biofilms, formed by clustered bacteria, adhere strongly to tooth enamel and gum crevices. Simple friction…
dCas9 Epigenome Editing Without Base Sequence Damage: A New Horizon for Breeding Climate-Resilient Crops Against Climate Crisis
Background As climate change accelerates, the frequency and intensity of abiotic stresses such as drought, salinity, and extreme heat are rising to unprecedented levels. Amidst serious threats to global food security, critics point out that existing breeding technologies and traditional genomic modifications are insufficient to respond agilely to complex env…
Next-Generation mRNA Cervical Cancer Vaccine Inducing Immunity Comparable to Gardasil-9 and the Establishment of Protective Thresholds
Background Cervical cancer is a major cause of cancer death among women worldwide, with most cases stemming from infection with high-risk Human Papillomavirus (HPV). Currently, recombinant protein Virus-Like Particle (VLP) vaccines such as Cervarix or GARDASIL 9 are used in clinical settings. While these vaccines, composed of the L1 capsid protein, exhibit e…
mRNA Therapy for Inflammatory Bowel Disease Delivered Directly to Colonic Lesions via Methylprednisolone-Derived Lipid Nanoparticles
Background Inflammatory bowel disease (IBD), represented by Crohn's disease and ulcerative colitis, is a refractory condition characterized by persistent chronic inflammation of the intestinal tract. Patients often suffer from frequent relapses, abdominal pain, and bloody stools, and many require lifelong medication. Currently, corticosteroids, biologics, an…
Maximizing Plant Prime Editing Efficiency to Precisively Introduce Pepper Resistance Mutations into Tomato for the Construction of Multidisease Resistance
Background Bacterial diseases are a major factor in drastically reducing yields in crop cultivation fields. As cultivation environments become unstable due to climate change, the importance of breeding technologies to secure resistance against complex pathogens has increased. Traditional breeding methods require multiple backcrosses to introduce desired resi…
Alzheimer's Treatment Strategy Beyond Single-Target Limitations: Convergence of Multi-Target Drugs and Brain-Targeted Nanoplatforms
Background Alzheimer's disease (AD) is a leading neurodegenerative disease that impairs cognitive function in tens of millions of people worldwide. For decades, the drug development sector has poured massive capital into developing single-target inhibitors to block amyloid-beta protein accumulation or remove tau protein tangles. Although antibody therapies h…
Triple Nano-platform Blocking CD44 Prevents Pancreatic Cancer Liver Metastasis Triggered by Dyslipidemic Fatty Liver
Background Pancreatic cancer is an incurable cancer with a 5-year survival rate of around 10% due to rare early symptoms and invasion into adjacent organs or blood vessels at the time of diagnosis. In particular, the frequency of early liver metastasis is high, and the median survival period for patients with distant metastasis is less than one year. Metabol…
Identification of Metabolic Switch Bypassing SMAD3 Inhibitor Resistance: Controlling Tumor Proliferation by Blocking Lactate Transporter MCT1
Background The Transforming Growth Factor-beta (TGF-β) signaling pathway is a key axis regulating not only cancer cell proliferation and metastasis but also immune evasion within the tumor microenvironment. For a long time, global pharmaceutical companies have invested massive capital into developing TGF-β inhibitors. However, despite extensive clinical tria…