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ProtocolCore

Suggested Protocols

Exploratory MVP

EVIDENCE-LINKED PROTOCOL LIBRARY

Find protocols in papers, then adapt them to your work

Keep the methods and evidence from each paper visible while changing numbers and conditions or adding steps to create your own protocol.

13

Available

141

Evaluated records PASS

24

Blind holdout PASS

16

Reserve unopened

Choose a protocol field

Only families with explicit sources and validation state are opened. Compare and adapt starters from foundational research through cloning, imaging, and gene or viral delivery.

Available

PRT-NA-FOUNDATION-001

Nucleic Acid Extraction, Purification & QC Foundation

A source-bounded foundation that locks the specimen, DNA or RNA target, and downstream use before one exact extraction profile and orthogonal concentration, purity, integrity, contamination, inhibition, and functional-fit review.

4 bounded workflows14 official referencesfoundation · no universal defaults
Open protocol family
Available

PRT-PROTEIN-PRODUCTION-P1D-001

Recombinant Protein Production Protocol

A source-bounded workflow for one of five routes: BL21/T7, HEK293 transient, CHO transient, CHO stable pool, or CHO clonal producer.

1 composer21 official references5 bounded routes
Open protocol family
Available

PRT-ANTIBODY-APPLICATION-P1C-001

Manual Antibody Application Protocols

An antibody identity, application-specific validation, control, and reagent-preparation foundation connects to manual Western blot, ELISA, IP/co-IP, ICC/IF, research IHC, and flow cytometry workflows.

8 manual workflows18 official references59 Bio-Toolkit candidates
Open protocol family
Available

PRT-PROTEIN-BOTTOMUP-NORM-001

Bottom-up LC–MS/MS Sample Preparation Protocol

A nine-stage workflow from quantified compatible protein solution through source-specific in-solution digestion, one exact RP peptide cleanup, and facility handoff.

1 bounded workflow18 official references9 workflow stages
Open protocol family
Available

PRT-PROTEIN-INTACT-CHARACTERIZATION-001

Intact Protein Characterization Evidence Record

A research workspace for material lineage and class-specific denaturing/native MS, relative SEC-UV, SEC-MALS, and relative native-gel observations with exact provenance.

5 evidence classes8 source profiles8 synthetic holdout PASS
Open protocol family
Available

PRT-CELL-CULTURE-COMPOSER-001

Cell Culture Lifecycle Protocol

One eight-stage record spanning cell selection and characterization, thawing, seeding, maintenance, passage, harvest, cryopreservation, and banking.

1 protocols19 official referencesLocally verified
Open protocol family
Available

PRT-NGS-NORM-002

NGS Library Preparation Protocols

Manufacturer-guided starters for short-read DNA, stranded mRNA, 16S amplicon, nanopore ligation, and single-cell 3′ sequencing.

10 records4 · Blind holdout PASSNR-5 sealed
Open protocol family
Available

PRT-PCR-NORM-002

PCR and Quantitative Amplification Protocols

Source-aware starters that keep conventional PCR, qPCR, RT-PCR, RT-qPCR, and dPCR/ddPCR design, reaction setup, amplification, and quality decisions distinct.

25 records10 · Blind holdout PASSNR-5 sealed
Open protocol family
Available

PRT-CRISPR-EXACT-VALIDATION-004

CRISPR / Genome Editing Protocols

Source-bound MVP starters that lock target and reference identity before one SpCas9 knockout, CBE, ABE, HDR, or prime-editing profile and its controls, delivery handoff, and validation contract.

7 source-bound starters18 evaluated source clusters5 inherited v3 full-body challenges · 1 fail-closed incomplete
Open protocol family
Available

PRT-CLONING-ENZYME-FOUNDATION-001

Cloning & Enzymes Protocols

Source-bound starters that lock an exact profile and revision before restriction-ligation, BsaI-HFv2 Type IIS, or NEBuilder HiFi homology part and junction planning.

12 records0 · Blind holdout PASSNR-5 sealed
Open protocol family
Available

PRT-GENE-DELIVERY-TRANSFECTION-001

Gene Delivery / Transfection Protocols

Source-bound starters that lock the cell, payload, reagent, vessel, and source scale before running either suspension HEK293 PEI-MAX antibody-DNA delivery or the exact MDA-MB-231 Lipofectamine 3000 24-well profile.

3 source-bound starters2 exact profiles2 blind claim checks
Open protocol family
Available

PRT-IMAGING-ANALYSIS-FOUNDATION-001

Imaging & Analysis Protocols

A fixed-cell fluorescence foundation from a completed specimen handoff through explicit widefield or confocal acquisition, immutable raw artifacts, processing, segmentation, measurements, and replicate-aware summaries.

14 records0 · Blind holdout PASSNR-5 sealed
Open protocol family
Available

PRT-VIRAL-DELIVERY-FOUNDATION-001

Viral Delivery Protocols

A research foundation whose exact AAV2 first child separately locks vector, construct, capsid, lot, institutional biosafety disposition reference, native physical-genome titer, target readiness, and outcome lineage.

12 records0 · Blind holdout PASSNR-5 sealed
Open protocol family