Partial Reprogramming: Realizing Reversal of Aging Until now, cellular aging has been considered an inevitable natural phenomenon, but it is now entering the realm of 'treatable diseases'. • Core Technology: The research team successfully reversed the biological clock of mice by several weeks using 'partial reprogramming' technology, which returns cells to a youthful state without losing their identity. • Mechanism of Action: This approach involves temporarily activating specific transcription factors to erase aging markers and restore tissue function to youthful levels. • Clinical Entry: This innovative approach is expected to undergo safety verification and enter its first human clinical trial by the end of this year (2026).

Redefining Sex Determination Mechanisms: The Power of Non-coding DNA Research results that overturn conventional textbook knowledge about sex determination have also been published. • New Key to Sex Reversal: A 'sex reversal' phenomenon, in which functional testicular tissue is formed in genetically female (XX) mice, has been observed with just a single edit of non-coding DNA, not the coding region of genes. This demonstrates that non-coding regions have core control over biological sex determination processes.

Precision Obesity Treatment: Personalized Prescriptions Based on Genetic Background An answer to the efficacy variation of GLP-1-based obesity treatments, which have garnered worldwide attention, has also been presented. • Personalized Strategy: Research findings have revealed that the weight loss effect of medications and the occurrence of side effects are greatly influenced by an individual's unique genetic markers. This suggests that obesity treatment will shift from 'universal prescriptions' to 'precision medicine' based on genetic analysis in the future.

Conclusion: Paradigm Shift in Aging and Metabolic Disease Treatment The series of discoveries reported here indicate that the era in which humans can more precisely control their biological destiny is nearing. A new paradigm in life sciences is unfolding, ranging from reversal of aging to understanding sex development disorders and personalized metabolic treatments.