Drug Loading Calculator
Calculate encapsulation efficiency (EE%) and drug loading (DL%) for nanoparticles (LNP, liposome, polymer).
mg
ENCAPSULATION EFFICIENCY
—%
DRUG LOADING
—%
FORMULAS
EE% = ((Total drug − Free drug) / Total drug) × 100
DL% = (Entrapped drug / (Entrapped drug + Carrier mass)) × 100
TYPICAL RANGES
- • LNP (mRNA/siRNA): EE 80–99%, DL 5–15%
- • Liposomes (small molecule): EE 30–90%, DL 1–10%
- • PLGA nanoparticles: EE 40–80%, DL 1–30%
- • Polymeric micelles: EE 20–70%, DL 5–25%