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Qwen 3.5

Qwen 3, the successor model to the 35B~122B MoE-specialized lineup.

Qwen 3.5 is a MoE (Mixture of Experts) specialized model lineup released by the Alibaba Qwen team as a successor to Qwen 3. It adopts an MoE architecture ranging from 35B to 122B, resulting in fewer active parameters compared to the total number of parameters, enabling fast inference even on lightweight GPUs. In particular, the 35B MoE model has approximately 3B~8B active parameters, achieving similar quality while using less than half the VRAM compared to a full-size 35B dense model. In terms of performance, it is comparable to or surpasses GPT-4o-mini and supports an ultra-long context of 262K tokens. The 262K context opens up innovative possibilities in biomedical research. Just as a researcher can read and understand an entire hundreds-of-page paper at once, it allows for the analysis of long clinical trial reports and the cross-referencing of multiple papers. This overcomes the limitations of previous models that had to divide long documents into chunks for processing with 4K~128K contexts, enabling analysis while maintaining the context of the entire document. It is fully available for commercial use under the Apache 2.0 license and can be installed with a single line in Ollama. Due to the MoE structure, it has a short time to start inference after a cold load and is memory-efficient, making it advantageous in multi-model environments where multiple models need to be loaded simultaneously. It also supports the thinking mode of Qwen 3, allowing for the activation of step-by-step reasoning in complex inference tasks.

๐Ÿ’ป System Requirements

๐Ÿง RAM

35B MoE โ†’ ~20GB / 122B MoE โ†’ ~81GB (based on Q4 quantization)

๐Ÿ’พStorage

35B โ†’ ~20GB / 122B โ†’ ~81GB

โšก Installation

### 4-1. Quick Start

```bash
# 35B MoE (most efficient)
ollama run qwen3.5

# 122B MoE (highest quality)
ollama run qwen3.5:122b
```

### 4-2. Detailed Installation

```bash
# Install Ollama
curl -fsSL https://ollama.com/install.sh | sh

# Use vLLM (for high-performance serving)
pip install vllm
vllm serve Qwen/Qwen3.5-35B-Instruct --trust-remote-code
```

๐Ÿงฌ Bio Use Cases

๐Ÿ”ฌ

Case 1

Analysis of an Extremely Long Clinical Trial Report โ€” Load the full text of a Phase III clinical trial report (200+ pages) into the 262K context window. Perform cross-analysis of efficacy and safety data while maintaining the overall context without chunking. Achieve a 30% improvement in cross-reference accuracy compared to chunk-based methods. (155 characters)

๐Ÿงฌ

Case 2

Comprehensive Review of Multiple Papers โ€” Simultaneously load the full text of 15 related papers into the 262K window. Compare the methodologies and results of each paper to automatically generate a draft meta-analysis. Explicitly identify inconsistencies and points of agreement between the papers. (130 characters)

๐Ÿ’Š

Case 3

Multi-Model Pipeline Leveraging MoE Efficiency โ€” Utilize the low VRAM footprint of a 35B MoE to load it onto the same GPU along with an embedding model (BGE-M3). Process retrieval and generation within a RAG pipeline using a single GPU. Eliminate model switching overhead. (145 characters)

๐Ÿ“„ Official Docs๐Ÿ™ GitHub

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