Disease Atlas / Disease detail

Progressive supranuclear palsy

An atlas of 4R-tau atypical parkinsonism, early falls, eye-movement, cognitive and swallowing problems, and symptomatic care.

progressive supranuclear palsy · PSP · Steele-Richardson-Olszewski syndrome

MONDO:0019037Public QA completeSource-bound · 4

Disease at a glance

Start with the essentials, then explore the patient and research views.

Public revision · 9b98086d2cf3

Disease class: PSP is a progressive neurodegenerative disorder.
Core mechanism: Abnormal 4R-tau accumulation is characteristic.
Genes or cause: Early imbalance and backward falls are common.
Typical features: Slow or restricted vertical eye movements are characteristic.
Variability: Axial rigidity, gait freezing, and speech change occur.
Diagnosis: Swallowing, cognitive, and behavioral problems can progress.
Management: Diagnosis is clinical without a single confirmatory test.
Treatment and research: MRI and testing help exclude mimics.
Reading evidence: Levodopa response may be limited.
Key caution: Fall prevention and walking aids are introduced early.

A structured guide for understanding the disease and preparing for clinical conversations.

PSP is a progressive neurodegenerative disorder.

Slow or restricted vertical eye movements are characteristic.

Abnormal 4R-tau accumulation is characteristic.

Early imbalance and backward falls are common.

Axial rigidity, gait freezing, and speech change occur.

Swallowing, cognitive, and behavioral problems can progress.

Diagnosis is clinical without a single confirmatory test.

MRI and testing help exclude mimics.

Multidisciplinary, palliative, and care planning begins early.

Falls, eye movement, swallowing, and care goals require review.

This material is for disease education and is not a personal diagnosis or treatment instruction.

A trial registry status does not establish efficacy or regulatory approval.