Disease Atlas / Disease detail

Granulomatosis with polyangiitis

An atlas of ANCA-associated small-vessel inflammation, ENT, lung and kidney disease, tissue diagnosis, and severity-based treatment.

granulomatosis with polyangiitis · GPA · Wegener granulomatosis

MONDO:0012105Public QA completeSource-bound · 4

Disease at a glance

Start with the essentials, then explore the patient and research views.

Public revision · 135c9ab756ce

Disease class: GPA is a systemic small-vessel vasculitis.
Core mechanism: Immune inflammation and granulomas damage tissues.
Genes or cause: Nasal, ear, and sinus involvement is common.
Typical features: Lung nodules, hemorrhage, and glomerulonephritis can occur.
Variability: Eyes, skin, and nerves can also be involved.
Diagnosis: Diagnosis integrates clinical, urine, imaging, and tissue findings.
Management: ANCA supports diagnosis but is not independently diagnostic.
Treatment and research: Organ-threatening status determines treatment intensity.
Reading evidence: Severe induction uses rituximab or cyclophosphamide.
Key caution: Glucocorticoids are used with a tapering plan.

A structured guide for understanding the disease and preparing for clinical conversations.

GPA is a systemic small-vessel vasculitis.

Lung nodules, hemorrhage, and glomerulonephritis can occur.

Immune inflammation and granulomas damage tissues.

Nasal, ear, and sinus involvement is common.

Eyes, skin, and nerves can also be involved.

Diagnosis integrates clinical, urine, imaging, and tissue findings.

ANCA supports diagnosis but is not independently diagnostic.

Organ-threatening status determines treatment intensity.

Kidney, lung, hearing, and treatment toxicity are monitored.

Organ risk, infection, and reproductive plans require review.

This material is for disease education and is not a personal diagnosis or treatment instruction.

A trial registry status does not establish efficacy or regulatory approval.