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Aspergillosis

An evidence-led atlas distinguishing allergic, chronic, and invasive Aspergillus disease, risk-based diagnosis, and antifungal care.

aspergillosis

MONDO:0005657Public QA completeSource-bound · 4

Disease at a glance

Start with the essentials, then explore the patient and research views.

Public revision · cb35cbafa3ad

Disease class
Aspergillosis is a group of diseases caused by environmental Aspergillus molds.
Core mechanism
Exposure usually occurs by inhaling airborne spores and is not generally person-to-person.
Genes or cause
Disease includes distinct allergic forms, aspergilloma, chronic pulmonary disease, and invasive infection.
Typical features
Cough, dyspnea, chest pain, and hemoptysis can occur depending on form but are nonspecific.
Variability
Neutropenia, hematologic malignancy, stem-cell or solid-organ transplantation, and substantial immunosuppression increase invasive-disease risk.
Diagnosis
Diagnosis integrates risk factors and imaging with culture, microscopy, histopathology, antigen, or molecular tests.
Management
Detection in a respiratory specimen alone does not establish invasive disease.
Treatment and research
Treatment is selected by distinguishing allergic, chronic, fungal-ball, and invasive forms.
Reading evidence
Voriconazole is used as primary therapy for many patients with invasive aspergillosis.
Key caution
Antifungal selection considers syndrome, organ function, drug interactions, exposure levels, and resistance risk.

For patients and families

A structured guide for understanding the disease and preparing for clinical conversations.

At a glance

Aspergillosis is a group of diseases caused by environmental Aspergillus molds.

Cough, dyspnea, chest pain, and hemoptysis can occur depending on form but are nonspecific.

How the disease works

Exposure usually occurs by inhaling airborne spores and is not generally person-to-person.

Disease includes distinct allergic forms, aspergilloma, chronic pulmonary disease, and invasive infection.

Why experiences vary

Neutropenia, hematologic malignancy, stem-cell or solid-organ transplantation, and substantial immunosuppression increase invasive-disease risk.

Diagnosis and management

Diagnosis integrates risk factors and imaging with culture, microscopy, histopathology, antigen, or molecular tests.

Treatment status

Detection in a respiratory specimen alone does not establish invasive disease.

Treatment is selected by distinguishing allergic, chronic, fungal-ball, and invasive forms.

Reading clinical trials

Clinical symptoms, imaging, and microbiologic markers are reassessed to follow response and recurrence.

Topics for a clinical visit

Clinical discussion should cover immune and lung risk factors, syndrome, specimen meaning, drug interactions, and response assessment.

Medical notice

This material is for disease education and is not a personal diagnosis or treatment instruction.

Evidence and sources

A trial registry status does not establish efficacy or regulatory approval.