BioPlayground

dna-repair-pathway — DNA 손상 복구 경로Lab

BER / NER / MMR / HR / NHEJ + FA (interstrand crosslink) integrated diagram + 6 damage types → pathway auto-branch + XP/Lynch/HBOC disease links (zero external libs, ko/en/ja).

BER / NER / MMR / HR / NHEJ + FA (interstrand crosslink)

DNA Repair Pathway Simulation

Select Damage Type

Cause: ROS, normal metabolism byproduct — 8-hydroxyguanine. Causes G:C → T:A transversion. OGG1 glycosylase target.

Active Pathways

BER (Base Excision Repair)

Pathway Diagram

100%
1. Recognition (glycosylase) 2. AP cleavage (APE1) 3. Resynthesis (Pol β) 4. Ligation (Lig III·I) DNA glycosylase recognizesdamaged base + cleavesN-glycosidic bond → APsite.
Step 1 / 4

Step Detail — Recognition (glycosylase)

DNA glycosylase recognizes damaged base + cleaves N-glycosidic bond → AP site.

Enzymes/Cofactors: OGG1, UNG, MUTYH

Repair Fidelity: High

Associated Diseases

MUTYH-Associated Polyposis (MAP)BER

Affected Genes: MUTYH

Fails to correct 8-oxoG:A → multiple colorectal polyps + CRC risk. Autosomal recessive.

Key terms (hover)

BERNERMMRHRNHEJglycosylaseAPE1XPCXPATFIIHMSH2RAD51BRCA1/2Ku70/80strand invasionD-loopLynchHBOC
Associated Diseases (전체 6)
  • NER — Xeroderma Pigmentosum (XP) (OMIM 278700 + Cleaver 1968 Nature)
  • MMR — Lynch Syndrome (HNPCC) (OMIM 120435 + Fishel 1993 Cell)
  • HR — HBOC (Hereditary Breast-Ovarian Cancer) (OMIM 113705 + Miki 1994 Science)
  • FA — Fanconi Anemia (FA) (OMIM 227650)
  • NHEJ — LIG4 Syndrome (OMIM 606593)
  • BER — MUTYH-Associated Polyposis (MAP) (OMIM 608456)

Tool Guide

Definition

dna-repair-pathway is a free interactive diagram tool integrating five DNA repair pathways (BER glycosylase → APE1 → Pol β → Lig III·I / NER XPC → XPA-TFIIH → XPF·XPG → Pol δ/ε / MMR MSH2-6 + MLH1-PMS2 → EXO1 / HR MRN → RPA → RAD51 → strand invasion / NHEJ Ku70/80 → DNA-PKcs → XLF-XRCC4-Lig IV) and the FA pathway (interstrand crosslinks), letting users pick from 6 damage types (8-oxoG / pyrimidine dimer / alkylation / mismatch / DSB in S-G2 / DSB in G1 / ICL) → auto-branch + disease links panel (XP=NER, Lynch=MMR, HBOC=HR BRCA1/2, FA=FA) on an in-house svg-zoom hook (Alberts Ch.5 / Friedberg / Lindahl 1993 Nature, zero npm).

Purpose

(1) Static 5+1 textbook pathway diagrams → integrated interactive diagram (2) Learn damage→pathway branching (which damage uses which pathway?) (3) Bake in clinical links to carcinogenesis/genetic disease (XP/Lynch/HBOC/FA) (4) Full molecular-level 5-pathway steps (glycosylase → APE1 → Pol β, etc.) (5) Zero external libs — replace Alberts diagrams with in-house SVG hierarchical layout

How to Use

① Zoom (wheel) + pan (drag) the integrated diagram → 5+1 pathways in one view ② Pick a damage type (6) → pathway auto-highlights + click-through step nodes • 8-oxoG → BER (OGG1 → APE1 → Pol β → Lig III·I) • Pyrimidine dimer (UV) → NER (XPC → XPA-TFIIH → XPF·XPG → Pol δ/ε → Lig I) • Mismatch (post-replicative) → MMR (MSH2-6 + MLH1-PMS2 → EXO1 → Pol δ → Lig I) • DSB in S/G2 → HR (MRN → RPA → RAD51 → strand invasion + Holliday resolution) • DSB in G1 → NHEJ (Ku70/80 → DNA-PKcs → pol μ/λ → XLF + XRCC4 + Lig IV) • ICL → FA + HR + NER integrated ③ Disease panel — XP (NER) / Lynch (MMR) / HBOC BRCA1/2 (HR) / FA (FA) ④ Hover 18 academic terms (BER / NER / MMR / HR / NHEJ + glycosylase / APE1 / XPC / MSH2 / RAD51 / Ku70-80 / strand invasion, etc.)

Examples

Example 1) 8-oxoG → BER (OGG1 → APE1 → Pol β → Lig III·I) auto-highlight Example 2) UV pyrimidine dimer → NER pathway + XP (Xeroderma pigmentosum) disease panel Example 3) Post-replicative mismatch → MMR pathway + Lynch syndrome (HNPCC) link Example 4) S/G2 DSB → HR (RAD51 strand invasion) + HBOC BRCA1/2 link Example 5) G1 DSB → NHEJ (Ku70/80 + Lig IV) — cell cycle phase branch Example 6) ICL → FA + HR + NER integrated — Fanconi anemia presentation