Concentration, Dose Prep & Solubility
Convert concentrations, plan study-group formulations, and compare solubility with dose-volume requirements.
Concentration & dose-preparation results
Choose a mode and enter values.
This is molecular-weight-based arithmetic. Confirm salt/free-base form, hydrate, purity, density, activity units, and significant figures separately.
Sources: BIPM SI Brochure; NIH/NCATS Assay Guidance Manual; FDA Strength Conversion in Drug Listing; ICH M9 solubility guidance.
Tool Guide
Definition
Concentration, Dose Prep & Solubility Calculator — Concentration mode converts mass and molar units by molecular weight; Dose Prep plans per-subject and study-group formulation quantities. Solubility mode compares measured solubility and a user-supplied maximum mL/kg with a target dose to derive required concentration, volume, coverage, and maximum dose.
Purpose
(1) Cross-check concentration between mg/mL and mM or µM (2) Plan per-subject and study-group preparation and aliquots (3) Calculate concentration required to fit a target dose within a supplied mL/kg (4) Inspect solubility coverage, improvement factor, and maximum dose
How to Use
① Choose concentration conversion, dose preparation, or solubility/dose feasibility. ② In solubility mode, enter measured solubility, molecular weight, target mg/kg, body weight, and a maximum mL/kg that you determine. ③ Enter a separate concentration margin if needed for precipitation or variability allowance. ④ Compare required concentration/volume and fold difference with the actual formulation conditions. You must validate the maximum mL/kg for the route, species, vehicle, and protocol.
Examples
Solubility example) measured 8 mg/mL, MW 400, target 20 mg/kg, 0.25 kg, user-supplied maximum 5 mL/kg, 25% margin → base required concentration 4 mg/mL; with margin 5 mg/mL → measured-solubility coverage 1.6× → required volume 2.5 mL/kg = 0.625 mL/subject → maximum 40 mg/kg at the entered volume limit This does not guarantee a dissolved state or determine route safety.